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Article

Generation of an induced pluripotent stem cell line (SSMCi002-A) from a pediatric dilated cardiomyopathy patient carrying heterozygous mutation in the TTN gene.

Stem cell research - 1 Feb 2026

Zhang Ning, Wang Yuanxi, Hou Jian, Zhang Yuling, Shan Yongli, Hu Yanli, Wang Cheng, Long Yan

Abstract excerpt

Dilated cardiomyopathy (DCM), a leading cause of sudden cardiac death and heart failure, represents one of the most common cardiomyopathies in pediatric patients. In this study, we established a pluripotent stem cell (iPSC) line derived from a pediatric DCM patient harboring a heterozygous missense mutation in the TTN (titin) gene and homozygous nonsense mutations in both the PRR32 and RBMXL3 genes. Reprogramming...

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Identifiers

PMID: 41496282
DOI: 10.1016/j.scr.2025.103893

Genes

TTN
PRR32
RBMXL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Generation of an induced pluripotent stem cell line (SSMCi002-A) from a pediatric dilated cardiomyopathy patient carrying heterozygous mutation in the TTN gene.PMID 41496282Read ↗

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