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Article

Generation of human induced pluripotent stem cell line derived from dilated cardiomyopathy with compound heterozygous TTN and TAB2 variants.

Stem cell research - 1 Mar 2026

Yuan Weihua, Gao Qiang, Liu Xiwang, Ying Liyang, Zhang Xicheng, Fan Xiangming

Abstract excerpt

Dilated cardiomyopathy (DCM) represents the most prevalent form of cardiomyopathy. Multiple genetic variants are linked to DCM severity. We have established a human induced pluripotent stem cell (iPSC) line derived from a DCM patient harboring the p.M17164T (c.51491T>C) and p.Y138C (c.413A>G) mutations in the Titin (TTN) gene, as well as the p.Q3_S5del (c.9_17del) deletion in the TAB2 gene. The established iPSCs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41643483
DOI: 10.1016/j.scr.2026.103916

Genes

TAB2
TTN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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