Article
Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene.
Stem cell research - 1 Mar 2023
Jeon Sae-Bom, Kim Hyoeun, Chun Kyeong-Hyeon, Oh Jaewon, Kwon Chulan, Choi Hyo-Kyoung, Kim Sangwoo, Kim Hyoung-Pyo, Kim In-Cheol, Yoo Jung-Yoon, Park Sahng Wook, Kang Seok-Min, Lee Seung-Hyun
Abstract excerpt
Cardiac muscle troponin T protein binds to tropomyosin and regulates the calcium-dependent actin-myosin interaction on thin filaments in cardiomyocytes. Recent genetic studies have revealed that TNNT2 mutations are strongly linked to dilated cardiomyopathy (DCM). In this study, we generated YCMi007-A, a human induced pluripotent stem cell (hiPSC) line from a DCM patient with a p. Arg205Trp mutation in the TNNT2...
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