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Conversion of hepatitis B virus relaxed circular to covalently closed circular DNA is supported in murine cells

9 Jul 2022

Abstract excerpt

Background & Aims: HBV has a narrow host restriction, with humans and chimpanzees representing the only known natural hosts. The molecular correlates of resistance in species that are commonly used in biomedical research, such as mice, are currently incompletely understood. Expression of human NTCP (hNTCP) in mouse hepatocytes enables HBV entry, but subsequently covalently closed circular (cccDNA) does not form...

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PMID: 36035363
DOI: 10.1016/j.jhepr.2022.100534

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