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Article

Genomic resources for dissecting the role of non-protein coding variation in gene-environment interactions.

Toxicology - 1 Aug 2020

Levings Daniel, Shaw Kirsten E, Lacher Sarah E

Abstract excerpt

The majority of single nucleotide variants (SNVs) identified in Genome Wide Association Studies (GWAS) fall within non-protein coding DNA and have the potential to alter gene expression. Non-protein coding DNA can control gene expression by acting as transcription factor (TF) binding sites or by regulating the organization of DNA into chromatin. SNVs in non-coding DNA sequences can disrupt TF binding and...

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Identifiers

PMID: 32450112
DOI: 10.1016/j.tox.2020.152505
PMCID: PMC7423718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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