Article
Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome.
Nature - 1 Jan 2000
Heilig R, Lemaire C, Mandel J L, Dandolo L, Amar L, Avner P
Abstract excerpt
Recent progress has resulted in part of the gene mutated in Duchenne and the milder Becker muscular dystrophies being cloned and has suggested that the gene itself extends over 1,000 to 2,000 kilobases (kb). To study how mutations in this gene affect muscle development and integrity, it would be of interest to have available a mouse model of the human disease. The mouse mdx mutation affects muscle and confers a...
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