Article
Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites.
Nature communications - 8 Aug 2024
Siegel Sasha V, Trimarsanto Hidayat, Amato Roberto, Murie Kathryn, Taylor Aimee R, Sutanto Edwin, Kleinecke Mariana, Whitton Georgia, Watson James A, Imwong Mallika, Assefa Ashenafi, Rahim Awab Ghulam, Nguyen Hoang Chau, Tran Tinh Hien, Green Justin A, Koh Gavin C K W, White Nicholas J, Day Nicholas, Kwiatkowski Dominic P, Rayner Julian C, Price Ric N, Auburn Sarah
Abstract excerpt
Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of antimalarial efficacy and transmission. Recurrent infections may arise from activation of dormant liver stages (relapse), blood-stage treatment failure (recrudescence) or reinfection. Molecular inference of familial relatedness (identity-by-descent or IBD) can help resolve the probable origin of recurrences. As whole genome...
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