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Article

Adaptive Mutation in the Main Protease Cleavage Site of Feline Coronavirus Renders the Virus More Resistant to Main Protease Inhibitors.

Journal of virology - 14 Sept 2022

Jiao Zhe, Yan Yuanyuan, Chen Yixi, Wang Gang, Wang Xiaowei, Li Lisha, Yang Mengfang, Hu Xiaoshuai, Guo Yilin, Shi Yuejun, Peng Guiqing

Abstract excerpt

The rapid global emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused serious health problems, highlighting the urgent need for antiviral drugs. The viral main protease (Mpro) plays an important role in viral replication and thus remains the target of choice for the prevention or treatment of several viral diseases due to high sequence and structural conservation. Prolonged use of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36000844
DOI: 10.1128/jvi.00907-22
PMCID: PMC9472640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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