Article
Deep whole-genome analysis of 494 hepatocellular carcinomas.
Nature - 1 Mar 2024
Chen Lei, Zhang Chong, Xue Ruidong, Liu Mo, Bai Jian, Bao Jinxia, Wang Yin, Jiang Nanhai, Li Zhixuan, Wang Wenwen, Wang Ruiru, Zheng Bo, Yang Airong, Hu Ji, Liu Ke, Shen Siyun, Zhang Yangqianwen, Bai Mixue, Wang Yan, Zhu Yanjing, Yang Shuai, Gao Qiang, Gu Jin, Gao Dong, Wang Xin Wei, Nakagawa Hidewaki, Zhang Ning, Wu Lin, Rozen Steven G, Bai Fan, Wang Hongyang
Abstract excerpt
Over half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China1-3. However, whole-genome analysis of hepatitis B virus (HBV)-associated HCC in Chinese individuals is limited4-8, with current analyses of HCC mainly from non-HBV-enriched populations9,10. Here we initiated the Chinese Liver Cancer Atlas (CLCA) project and performed deep whole-genome sequencing (average depth, 120×) of 494 HCC...
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