Article
Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.
EBioMedicine - 1 Jul 2016
Feng Xiujing, Weng Dan, Zhou Feifei, Owen Young D, Qin Haohan, Zhao Jingfa, WenYu, Huang Yahong, Chen Jiajia, Fu Haijian, Yang Nanfei, Chen Dianhua, Li Jianxin, Tan Renxiang, Shen Pingping
Abstract excerpt
PPARγ has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds and activates PPARγ by acting as a modulator. Activation of PPARγ by apigenin blocks p65 translocation into nuclei through inhibition of p65/PPARγ complex translocation into nuclei, thereby decreasing NF-κB activation and favoringM2 macrophage...
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