Article
The A to I editing landscape in melanoma and its relation to clinical outcome.
RNA biology - 1 Jan 2022
Amweg Austeja, Tusup Marina, Cheng Phil, Picardi Ernesto, Dummer Reinhard, Levesque Mitchell P, French Lars E, Guenova Emmanuella, Läuchli Severin, Kundig Thomas, Mellett Mark, Pascolo Steve
Abstract excerpt
RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various cancer tissues. However, RNA editing can also generate neo-antigens that expose tumour cells to host immunosurveillance. Global RNA editing in melanoma and its...
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