Article
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication.
Molecular psychiatry - 1 Nov 2010
Arcos-Burgos M, Jain M, Acosta M T, Shively S, Stanescu H, Wallis D, Domené S, Vélez J I, Karkera J D, Balog J, Berg K, Kleta R, Gahl W A, Roessler E, Long R, Lie J, Pineda D, Londoño A C, Palacio J D, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog P M, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga J A, Hervas A, Maher B S, Faraone S V, Seitz C, Freitag C M, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch K-P, Swanson J, Vortmeyer A, Bailey-Wilson J E, Castellanos F X, Muenke M
Abstract excerpt
Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For our statistical approach, we started with a linkage study based on large multigenerational families in a population isolate, followed by...
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