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Article

RB1 loss triggers dependence on ESRRG in retinoblastoma

19 Aug 2022

Abstract excerpt

Retinoblastoma (Rb) is a deadly childhood eye cancer that is classically initiated by inactivation of the RB1 tumor suppressor. Clinical management continues to rely on nonspecific chemotherapeutic agents that are associated with treatment resistance and toxicity. Here, we analyzed 103 whole exomes, 20 whole transcriptomes, 5 single-cell transcriptomes, and 4 whole genomes from primary Rb tumors to identify...

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PMID: 35984874
DOI: 10.1126/sciadv.abm8466

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