Article
Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis.
Molecular oncology - 1 Oct 2022
Ran Rensen, Li Lanxin, Shi Zhaoying, Liu Guanghui, Jiang Hao, Fang Liangchen, Xu Tingting, Huang Jixuan, Chen Weiqi, Chen Yonglong
Abstract excerpt
In humans, germline TP53 mutations predispose carriers to a wide spectrum of cancers, which is known as Li-Fraumeni syndrome (LFS). To date, the association of melanomas with LFS remains unestablished. No melanomas have been reported in any P53-modified mouse models either. In this study, we show that targeted disruption of P53 at the DNA-binding domain in Xenopus tropicalis recapitulates LFS, with the formation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.