Melanoma in patients with Li‑Fraumeni syndrome (Review)

Abstract excerpt

Li‑Fraumeni syndrome (LFS) is a cancer‑prone, autosomal dominant syndrome caused by underlying germline gene mutations of TP53, a tumor‑suppressor gene encoding the p53 protein with a major role in apoptosis, DNA repair and cell cycle regulation. Cumulative cancer incidence for LFS patients by the age of 70 years is 80‑100%, mostly involving adrenocortical carcinoma, brain tumors, bone and soft tissue sarcomas,...

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