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Article

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype.

Nature communications - 31 Mar 2023

Wu Xin-Hua, He Yang-Yang, Chen Zhang-Rong, He Ze-Yuan, Yan Yi, He Yangzhige, Wang Guang-Ming, Dong Yu, Yang Ying, Sun Yi-Min, Ren Yong-Hong, Zhao Qiu-Yan, Yang Xiao-Dan, Wang Li-Ying, Fu Cai-Jun, He Miao, Zhang Si-Jin, Fu Ji-Fen, Liu Hong, Jing Zhi-Cheng

Abstract excerpt

Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about the immune landscape in peripheral circulation in patients with high-altitude pulmonary hypertension (HAPH). We apply single-cell transcriptomics to characterize the monocytes that are significantly enriched in the peripheral blood mononuclear cells (PBMC) of HAPH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37002243
DOI: 10.1038/s41467-023-37527-4
PMCID: PMC10066231

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