Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia.

doi:10.1038/s41408-022-00712-7

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Article

Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia.

Blood cancer journal - 16 Aug 2022

Vergez François, Largeaud Laetitia, Bertoli Sarah, Nicolau Marie-Laure, Rieu Jean-Baptiste, Vergnolle Inès, Saland Estelle, Sarry Audrey, Tavitian Suzanne, Huguet Françoise, Picard Muriel, Vial Jean-Philippe, Lechevalier Nicolas, Bidet Audrey, Dumas Pierre-Yves, Pigneux Arnaud, Luquet Isabelle, Mansat-De Mas Véronique, Delabesse Eric, Carroll Martin, Danet-Desnoyers Gwenn, Sarry Jean-Emmanuel, Récher Christian

Abstract excerpt

Classifications of acute myeloid leukemia (AML) patients rely on morphologic, cytogenetic, and molecular features. Here we have established a novel flow cytometry-based immunophenotypic stratification showing that AML blasts are blocked at specific stages of differentiation where features of normal myelopoiesis are preserved. Six stages of leukemia differentiation-arrest categories based on CD34, CD117, CD13,...

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PMID: 35973983
DOI: 10.1038/s41408-022-00712-7
PMCID: PMC9381519

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