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Gene/environment interaction in the susceptibility of Crohn's disease patients to aluminum

13 Aug 2022

Abstract excerpt

BACKGROUND & AIM: The key role of environmental factors in the pathogenesis of Inflammatory Bowel Diseases (IBD) is recognized. Aluminum is suspected to be a risk factor for IBD. However, mechanisms linking aluminum exposure to disease development are unknown. We examined the role of aluminum transport and subcellular localisation on human colon susceptibility to aluminum-induced inflammation. METHODS: Human...

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PMID: 35973536
DOI: 10.1016/j.scitotenv.2022.158017

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