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Dynamics of Chikungunya Virus Cell Entry Unraveled by Single-Virus Tracking in Living Cells

25 Feb 2016

Abstract excerpt

UNLABELLED: Chikungunya virus (CHIKV) is a rapidly emerging mosquito-borne human pathogen causing major outbreaks in Africa, Asia, and the Americas. The cell entry pathway hijacked by CHIKV to infect a cell has been studied previously using inhibitory compounds. There has been some debate on the mechanism by which CHIKV enters the cell: several studies suggest that CHIKV enters via clathrin-mediated endocytosis,...

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PMID: 26912616
DOI: 10.1128/jvi.03184-15

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