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Article

In situ fate of Chikungunya virus replication organelles

28 Jun 2024

Abstract excerpt

ABSTRACT Chikungunya virus (CHIKV) is a mosquito-borne pathogen responsible for an acute musculoskeletal disease in humans. Replication of the viral RNA genome occurs in specialized membranous replication organelles (ROs) or spherules, which contain the viral replication complex. Initially generated by RNA synthesis-associated plasma membrane deformation, alphavirus ROs are generally rapidly endocytosed to...

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PMID: 38940586
DOI: 10.1128/jvi.00368-24

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