Article
A tightly clustered hepatitis E virus genotype 1a is associated with endemic and outbreak infections in Bangladesh.
PloS one - 1 Jan 2021
Hoa Trang Nguyen, Munshi Saif Ullah, Ngoc Khanh Nguyen, Ngoc Chau Le, Thanh Thanh Tran Thi, Akther Tahmina, Tabassum Shahina, Parvin Nilufa, Baker Stephen, Rahman Motiur
Abstract excerpt
BACKGROUND: Hepatitis E virus (HEV) infection is endemic in Bangladesh and there are occasional outbreaks. The molecular characteristics and pathogenesis of endemic and outbreak HEV strains are poorly understood. We compared the genetic relatedness and virulence associated mutations of endemic HEV strains with outbreak strains. METHODS: We analyzed systematically collected serum samples from HEV immunoglobulin M...
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