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Article

KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN - 1 Sept 2022

Rah Gyuyeong, Cha Hwayeon, Kim Joohee, Song Jieun, Kim Hyunho, Oh Yun Kyu, Ahn Curie, Kang Minyong, Kim Jongmin, Yoo Kyung Hyun, Kim Min Jung, Ko Hyuk Wan, Ko Je Yeong, Park Jong Hoon

Abstract excerpt

BACKGROUND: Ciliogenesis-associated kinase 1 (CILK1) is a ciliary gene that localizes in primary cilia and regulates ciliary transport. Mutations in CILK1 cause various ciliopathies. However, the pathogenesis of CILK1-deficient kidney disease is unknown. METHODS: To examine whether CILK1 deficiency causes PKD accompanied by abnormal cilia, we generated mice with deletion of Cilk1 in cells of the renal collecting...

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Identifiers

PMID: 35961787
DOI: 10.1681/ASN.2021111455
PMCID: PMC9529174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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