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Article

Circulating Tumor DNA Allele Fraction: A Candidate Biological Signal for Multicancer Early Detection Tests to Assess the Clinical Significance of Cancers.

The American journal of pathology - 1 Oct 2022

Bredno Joerg, Venn Oliver, Chen Xiaoji, Freese Peter, Ofman Joshua J

Abstract excerpt

Current imaging-based cancer screening approaches provide useful but limited prognostic information. Complementary to existing screening tests, cell-free DNA-based multicancer early detection (MCED) tests account for cancer biology [manifested through circulating tumor allele fraction (cTAF)], which could inform prognosis and help assess the cancer's clinical significance. This review discusses the factors...

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Identifiers

PMID: 35948080
DOI: 10.1016/j.ajpath.2022.07.007

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