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SMaSH: a scalable, general marker gene identification framework for single-cell RNA-sequencing

8 Aug 2022

Abstract excerpt

BACKGROUND: Single-cell RNA-sequencing is revolutionising the study of cellular and tissue-wide heterogeneity in a large number of biological scenarios, from highly tissue-specific studies of disease to human-wide cell atlases. A central task in single-cell RNA-sequencing analysis design is the calculation of cell type-specific genes in order to study the differential impact of different replicates (e.g. tumour...

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PMID: 35941549
DOI: 10.1186/s12859-022-04860-2

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