Zika virus NS4A hijacks host ANKLE2 to promote viral replication

Abstract excerpt

Zika virus (ZIKV) is infamous among flaviviruses for its unique association with congenital birth defects, notably microcephaly. We previously mapped ZIKV-host protein interactions and identified the interaction between ZIKV NS4A and host ANKLE2, which itself has established ties to congenital microcephaly. In fruit flies, NS4A induces microcephaly phenotypes in an ANKLE2-dependent manner. This suggests that NS4A...

Topics

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• Eye
• Insect symbiosis and bacterial influences
• Janus Kinases
• Mosquito-borne diseases and control
• Receptors, Notch
• STAT Transcription Factors
• Veins
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

564d7a00-01e7-5be9-b4b3-3d69ca5da867

DOI

10.1101/2022.03.15.484510