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Article

Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide.

Neuroscience and biobehavioral reviews - 1 May 2009

Savitz Jonathan, Drevets Wayne C

Abstract excerpt

Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature. Here, we attempt a comprehensive review of MRI and metabolic PET studies conducted to date on these two disorders, and interpret our findings from the perspective of developmental and degenerative models of illness. Elevated activity and volume loss of the hippocampus, orbital and ventral...

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Identifiers

PMID: 19428491
DOI: 10.1016/j.neubiorev.2009.01.004
PMCID: PMC2858318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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