Article
Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes.
The Journal of clinical investigation - 3 Oct 2022
Elagib Kamaleldin E, Brock Ashton, Clementelli Cara M, Mosoyan Goar, Delehanty Lorrie L, Sahu Ranjit K, Pacheco-Benichou Alexandra, Fruit Corinne, Besson Thierry, Morris Stephan W, Eto Koji, Jobaliya Chintan, French Deborah L, Gadue Paul, Singh Sandeep, Shi Xinrui, Qin Fujun, Cornelison Robert, Li Hui, Iancu-Rubin Camelia, Goldfarb Adam N
Abstract excerpt
Infantile (fetal and neonatal) megakaryocytes (Mks) have a distinct phenotype consisting of hyperproliferation, limited morphogenesis, and low platelet production capacity. These properties contribute to clinical problems that include thrombocytopenia in neonates, delayed platelet engraftment in recipients of cord blood stem cell transplants, and inefficient ex vivo platelet production from pluripotent stem...
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