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Article

Genistein Targets STING-Driven Antiviral Responses

4 Aug 2022

Abstract excerpt

Several reports suggest that Genistein exhibits antiviral activities against DNA viruses. Our work uncovers a previously unrecognized proviral effect of Genistein, through inhibition of the cGAS-STING pathway at the level of cGAMP transfer and its sensing by STING. This suggests that the use of Genistein as an antiviral should be taken with caution as it may reduce the protective antiviral effects elicited by...

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PMID: 35924852
DOI: 10.1128/mbio.02064-22

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