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Article

Hemagglutinin mutations related to antigenic variation in H1 swine influenza viruses.

Journal of virology - 1 Feb 1992

Luoh S M, McGregor M W, Hinshaw V S

Abstract excerpt

The hemagglutinin (HA) of a recent swine influenza virus, A/Sw/IN/1726/88 (H1N1), was shown previously to have four antigenic sites, as determined from analysis of monoclonal antibody (MAb)-selected escape mutants. To define the HA mutations related to these antigenic sites, we cloned and sequenced the HA genes amplified by polymerase chain reaction of parent virus and MAb-selected escape mutants. The genetic...

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Identifiers

PMID: 1731091
DOI: 10.1128/JVI.66.2.1066-1073.1992
PMCID: PMC240810

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