Article
Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine.
Journal of virology - 1 May 2014
Lewis Nicola S, Anderson Tavis K, Kitikoon Pravina, Skepner Eugene, Burke David F, Vincent Amy L
Abstract excerpt
UNLABELLED: Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine influenza A vaccines. However, as a result of antigenic drift, vaccine strains must be regularly updated to reflect currently circulating strains....
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