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Article

Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.

Human molecular genetics - 1 Jan 2023

Fischer Julie A, Monroe Tanner O, Pesce Lorenzo L, Sawicki Konrad T, Quattrocelli Mattia, Bauer Rosemary, Kearns Samuel D, Wolf Matthew J, Puckelwartz Megan J, McNally Elizabeth M

Abstract excerpt

Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant allele frequencies in cardiomyopathy cases versus controls identified the MTCH2 gene as having unusual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35904451
DOI: 10.1093/hmg/ddac176
PMCID: PMC9837833

Genes

MTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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