Article
Multiplex Epstein-Barr virus BALF2 genotyping detects high-risk variants in plasma for population screening of nasopharyngeal carcinoma.
Molecular cancer - 28 Jul 2022
Miller Jacob A, Sahoo Malaya K, Yamamoto Fumiko, Huang ChunHong, Wang Hannah, Zehnder James L, Le Quynh-Thu, Pinsky Benjamin A
Abstract excerpt
BACKGROUND: Epstein-Barr Virus (EBV)-associated nasopharyngeal carcinoma (NPC) exhibits unusual geographic restriction despite ubiquitous lifelong infection. Screening programs can detect most NPC cases at an early stage, but existing EBV diagnostics are limited by false positives and low positive predictive value (PPV), leading to excess screening endoscopies, MRIs, and repeated testing. Recent EBV genome-wide...
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