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Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

27 Jul 2022

Abstract excerpt

Innate lymphoid cells (ILCs) include cytotoxic natural killer cells and distinct groups of cytokine-producing innate helper cells which participate in immune defense and promote tissue homeostasis. Circulating human ILC precursors (ILCP) able to generate all canonical ILC subsets via multi-potent or uni-potent intermediates according to our previous work. Here we show potential cooperative roles for the Notch and...

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PMID: 35896601
DOI: 10.1038/s41467-022-32089-3

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