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Article

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding.

Cell reports - 3 Aug 2021

Trimpert Jakob, Dietert Kristina, Firsching Theresa C, Ebert Nadine, Thi Nhu Thao Tran, Vladimirova Daria, Kaufer Susanne, Labroussaa Fabien, Abdelgawad Azza, Conradie Andelé, Höfler Thomas, Adler Julia M, Bertzbach Luca D, Jores Joerg, Gruber Achim D, Thiel Volker, Osterrieder Nikolaus, Kunec Dusan

Abstract excerpt

Safe and effective vaccines are urgently needed to stop the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live attenuated vaccine candidates by large-scale recoding of the SARS-CoV-2 genome and assess their safety and efficacy in Syrian hamsters. Animals were vaccinated with a single dose of the respective recoded virus and challenged 21 days later. Two...

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Identifiers

PMID: 34320400
DOI: 10.1016/j.celrep.2021.109493
PMCID: PMC8289629

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