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Article

Cyclic Hypoxia Induces Transcriptomic Changes in Mast Cells Leading to a Hyperresponsive Phenotype after FcεRI Cross-Linking.

Cells - 19 Jul 2022

Segura-Villalobos Deisy, Lamas Monica, González-Espinosa Claudia

Abstract excerpt

Mast cells (MCs) play important roles in tumor development, executing pro- or antitumoral functions depending on tumor type and tumor microenvironment (TME) conditions. Cyclic hypoxia (cyH) is a common feature of TME since tumor blood vessels fail to provide a continuous supply of oxygen to the tumor mass. Here, we hypothesized that the localization of MCs in cyH regions within solid tumors could modify their...

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PMID: 35883682
DOI: 10.3390/cells11142239
PMCID: PMC9319477

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