Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases.

Immunity - 19 Nov 2019

Cildir Gökhan, Toubia John, Yip Kwok Ho, Zhou Mingyan, Pant Harshita, Hissaria Pravin, Zhang Jingxian, Hong Wanjin, Robinson Nirmal, Grimbaldeston Michele A, Lopez Angel F, Tergaonkar Vinay

Abstract excerpt

Mast cells (MCs) are versatile immune cells capable of rapidly responding to a diverse range of extracellular cues. Here, we mapped the genomic and transcriptomic changes in human MCs upon diverse stimuli. Our analyses revealed broad H3K4me3 domains and enhancers associated with activation. Notably, the rise of intracellular calcium concentration upon immunoglobulin E (IgE)-mediated crosslinking of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Fibrinogen

Share to Histones

Share to Hypersensitivity

Share to Immunoglobulin E

Share to Mast Cells

Source

Identifiers

PMID: 31653482
DOI: 10.1016/j.immuni.2019.09.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases.PMID 31653482Read ↗

Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcεRI-aggregation reveals a complex network of genes involved in inflammatory responsesSemantic proximity Read ↗

Redefinition of the human mast cell transcriptome by deep-CAGE sequencingSemantic proximity Read ↗

The transcriptional program, functional heterogeneity, and clinical targeting of mast cellsSemantic proximity Read ↗

Whole-Exome Sequencing: Discovering Genetic Causes of Granulomatous MastitisSemantic proximity Read ↗

Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasisSemantic proximity Read ↗

Mast cells signal their importance in health and diseaseSemantic proximity Read ↗

Genome-wide meta-analysis implicates variation affecting mast cell biology in urticaria.Semantic proximity Read ↗

Transcriptome-wide Association Study of Circulating IgE Levels Identifies Novel Targets for Asthma and Allergic DiseasesSemantic proximity Read ↗

Mast Cells as Drivers of Disease and Therapeutic TargetsSemantic proximity Read ↗

A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.Semantic proximity Read ↗

Multi-omics analysis reveals vitamin D metabolism, hyper-IgE genes, and epithelial barrier dysfunction in hazelnut allergySemantic proximity Read ↗

Epigenetic and transcriptional control of mast cell responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.