Article
Influence of germline BRCA genotype on the survival of patients with triple-negative breast cancer.
Cancer research communications - 1 Dec 2021
Villarreal-Garza Cynthia, Ferrigno Ana S, Aranda-Gutierrez Alejandro, Frankel Paul H, Ruel Nora H, Fonseca Alan, Narod Steven, Chavarri-Guerra Yanin, Sifuentes Erika, Magallanes-Hoyos Maria Cristina, Herzog Josef, Castillo Danielle, Alvarez-Gomez Rosa M, Mohar-Betancourt Alejandro, Weitzel Jeffrey N
Abstract excerpt
The presence of BRCA pathogenic variants (PVs) in triple-negative breast cancer (TNBC) is associated with a distinctive genomic profile that makes the tumor particularly susceptible to DNA-damaging treatments. However, patients with BRCA PVs can develop treatment resistance through the appearance of reversion mutations and restored BRCA expression. As copy-number variants (CNV) could be less susceptible to...
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