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Article

Significant clinical impact of recurrent BRCA1 and BRCA2 mutations in Mexico.

Cancer - 1 Feb 2015

Villarreal-Garza Cynthia, Alvarez-Gómez Rosa María, Pérez-Plasencia Carlos, Herrera Luis A, Herzog Josef, Castillo Danielle, Mohar Alejandro, Castro Clementina, Gallardo Lenny N, Gallardo Dolores, Santibáñez Miguel, Blazer Kathleen R, Weitzel Jeffrey N

Abstract excerpt

BACKGROUND: Frequent recurrent mutations in the breast and ovarian cancer susceptibility (BRCA) genes BRCA1 and BRCA2 among Hispanics, including a large rearrangement Mexican founder mutation (BRCA1 exon 9-12 deletion [ex9-12del]), suggest that an ancestry-informed BRCA-testing strategy could reduce disparities and promote cancer prevention by enabling economic screening for hereditary breast and ovarian cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25236687
DOI: 10.1002/cncr.29058
PMCID: PMC4304938

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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