A functional BRCA1 coding sequence genetic variant contributes to prognosis of triple-negative breast cancer, especially after radiotherapy.

doi:10.1007/s10549-017-4395-1

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A functional BRCA1 coding sequence genetic variant contributes to prognosis of triple-negative breast cancer, especially after radiotherapy.

Breast cancer research and treatment - 1 Nov 2017

Shi Meng, Ma Fei, Liu Jibing, Xing Huaixin, Zhu Hui, Yu Jinming, Yang Ming

Abstract excerpt

PURPOSE: As a subtype of breast cancer, triple-negative breast cancer (TNBC) shows poor prognosis and high heterogeneity. Precise identification of TNBC subgroups relevant to clinical prognosis is crucial in the design and administration of individualized treatments. This study aimed to evaluate the prognostic value of the functional BRCA1 rs799917 genetic variant in TNBC. METHODS: Associations between the...

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PMID: 28744749
DOI: 10.1007/s10549-017-4395-1

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