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Article

Somatic mutations in DCC are associated with genomic instability and favourable outcomes in melanoma patients treated with immune checkpoint inhibitors.

British journal of cancer - 1 Nov 2022

Li Yuting, Wang Qinghua, Chen Yang, Zhao Lujun

Abstract excerpt

BACKGROUND: Deleted in colorectal cancer (DCC) encodes a transmembrane dependence receptor and is frequently mutated in melanoma. The associations of DCC mutation with chromosomal instability and immunotherapeutic efficacy in melanoma are largely uncharacterised. METHODS: We performed an integrated study based on biological experiments and multi-dimensional data types, including genomic, transcriptomic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35871235
DOI: 10.1038/s41416-022-01921-4
PMCID: PMC9553921

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