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Article

Primary and Metastatic Melanoma With NTRK Fusions.

The American journal of surgical pathology - 1 Aug 2018

Lezcano Cecilia, Shoushtari Alexander N, Ariyan Charlotte, Hollmann Travis J, Busam Klaus J

Abstract excerpt

A number of oncogenic driver mutations have been identified in melanocytic nevi and melanoma, but translocations also play a role in tumorigenesis and provide potential therapeutic targets for malignant lesions. Various translocations, such as those involving the anaplastic lymphoma kinase (ALK), neurotrophic tropomyosin receptor kinase 1 (NTRK1), and NTRK3 have been reported in spitzoid melanocytic neoplasms...

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Topics

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Share to Gene Fusion
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Glycoproteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 29683819
DOI: 10.1097/PAS.0000000000001070
PMCID: PMC6041134

Genes

ALK
NTRK1
NTRK2
DDR2
NTRK3
TRAF2
TRIM63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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