Article
Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.
American journal of respiratory and critical care medicine - 15 Jun 2018
Mak Angel C Y, White Marquitta J, Eckalbar Walter L, Szpiech Zachary A, Oh Sam S, Pino-Yanes Maria, Hu Donglei, Goddard Pagé, Huntsman Scott, Galanter Joshua, Wu Ann Chen, Himes Blanca E, Germer Soren, Vogel Julia M, Bunting Karen L, Eng Celeste, Salazar Sandra, Keys Kevin L, Liberto Jennifer, Nuckton Thomas J, Nguyen Thomas A, Torgerson Dara G, Kwok Pui-Yan, Levin Albert M, Celedón Juan C, Forno Erick, Hakonarson Hakon, Sleiman Patrick M, Dahlin Amber, Tantisira Kelan G, Weiss Scott T, Serebrisky Denise, Brigino-Buenaventura Emerita, Farber Harold J, Meade Kelley, Lenoir Michael A, Avila Pedro C, Sen Saunak, Thyne Shannon M, Rodriguez-Cintron William, Winkler Cheryl A, Moreno-Estrada Andrés, Sandoval Karla, Rodriguez-Santana Jose R, Kumar Rajesh, Williams L Keoki, Ahituv Nadav, Ziv Elad, Seibold Max A, Darnell Robert B, Zaitlen Noah, Hernandez Ryan D, Burchard Esteban G
Abstract excerpt
RATIONALE: Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response. OBJECTIVES: To identify genetic variants important for bronchodilator drug response (BDR) in racially diverse children. METHODS: We performed the first whole-genome sequencing pharmacogenetics study from 1,441 children with asthma from the...
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