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Article

Multi-omic approach associates blood methylome with bronchodilator drug response in pediatric asthma

14 Feb 2023

Abstract excerpt

BACKGROUND: Albuterol is the drug most widely used as asthma treatment among African Americans despite having a lower bronchodilator drug response (BDR) than other populations. Although BDR is affected by gene and environmental factors, the influence of DNA methylation is unknown. OBJECTIVE: This study aimed to identify epigenetic markers in whole blood associated with BDR, study their functional consequences by...

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PMID: 36796456
DOI: 10.1016/j.jaci.2023.01.026

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