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Article

Pleural Fluid Cytology Detects Small Cell Carcinoma Transformation in EGFR-Mutant Lung Adenocarcinoma: A Case Report.

Diagnostic cytopathology - 1 Oct 2026

Zhou Huijun, He Zhengyue, Wang Zhuo, Zhao Sihan, Zheng Chang, Liang Yanli, Liu Lianghua

Abstract excerpt

BACKGROUND: Histological transformation of lung adenocarcinoma to small cell carcinoma is a rare but critical mechanism of acquired resistance to EGFR-TKIs. CASE: A 65-year-old woman with EGFR-mutant lung adenocarcinoma developed new-onset massive pleural effusion after an initial partial response to icotinib. Pleural fluid cytology revealed tumor cells with high nuclear-to-cytoplasmic ratio, finely granular...

Read the complete abstract on PubMed

Topics

Humans
Female
Aged
ErbB Receptors
Lung Neoplasms
Adenocarcinoma of Lung
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Transformation, Neoplastic

Small Cell Lung Carcinoma

Pleural Effusion, Malignant

Source

Open in PubMed Open full text

Identifiers

PMID: 42411651
DOI: 10.1002/dc.70177
PMCID: PMC13532635

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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