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Article

Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71.

PloS one - 1 Jan 2013

Lin Yi-Wen, Yu Shu-Ling, Shao Hsiao-Yun, Lin Hsiang-Yin, Liu Chia-Chyi, Hsiao Kuang-Nan, Chitra Ebenezer, Tsou Yueh-Liang, Chang Hsuen-Wen, Sia Charles, Chong Pele, Chow Yen-Hung

Abstract excerpt

Enterovirus 71 (EV71) and coxsackievirus (CVA) are the most common causative factors for hand, foot, and mouth disease (HFMD) and neurological disorders in children. Lack of a reliable animal model is an issue in investigating EV71-induced disease manifestation in humans, and the current clinical therapies are symptomatic. We generated a novel EV71-infectious model with hSCARB2-transgenic mice expressing the...

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Identifiers

PMID: 23451246
DOI: 10.1371/journal.pone.0057591
PMCID: PMC3581494

Genes

SCARB2
CCL3
CXCL10
TNF

Provenance

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