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Article

ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype.

Oncogene - 1 Jun 2020

Portney Benjamin A, Arad Michal, Gupta Aditi, Brown Robert A, Khatri Raju, Lin Phyo Nay, Hebert Andrea M, Angster Kristen H, Silipino Lorna E, Meltzer W Alex, Taylor Rodney J, Zalzman Michal

Abstract excerpt

Cancer stem cells (CSCs) are cells within tumors that maintain the ability to self-renew, drive tumor growth, and contribute to therapeutic resistance and cancer recurrence. In this study, we investigate the role of Zinc finger and SCAN domain containing 4 (ZSCAN4) in human head and neck squamous cell carcinoma (HNSCC). The murine Zscan4 is involved in telomere maintenance and genomic stability of mouse embryonic...

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Share to Acetylation
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Nanog Homeobox Protein

Share to Neoplastic Stem Cells

Share to Octamer Transcription Factor-3

Source

Open in PubMed Open full text

Identifiers

PMID: 32507861
DOI: 10.1038/s41388-020-1333-1
PMCID: PMC7314663

Genes

ZSCAN4
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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