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Article

The role of ARMC5 in human cell cultures from nodules of primary macronodular adrenocortical hyperplasia (PMAH).

Molecular and cellular endocrinology - 15 Jan 2018

Cavalcante Isadora P, Nishi Mirian, Zerbini Maria Claudia N, Almeida Madson Q, Brondani Vania B, Botelho Maria Luiza Anhaia de Arruda, Tanno Fabio Y, Srougi Victor, Chambo José Luis, Mendonca Berenice B, Bertherat Jérôme, Lotfi Claudimara F P, Fragoso Maria Candida B V

Abstract excerpt

The participation of aberrant receptors and intra-adrenal ACTH in hyperplastic tissue are considered mechanisms that regulate hypercortisolism in PMAH. Additionally, germline ARMC5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with PMAH. Previous functional studies analyzed ARMC5 role using H295R cells. Therefore, we investigated the role of ARMC5 in cell...

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Identifiers

PMID: 28676429
DOI: 10.1016/j.mce.2017.06.027

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CCNE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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