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Smooth Muscle Cell Klf4 Expression Is Not Required for Phenotype Modulation or Aneurysm Formation in Marfan Syndrome Mice-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2023

Pedroza Albert J, Dalal Alex R, Shad Rohan, Yokoyama Nobu, Nakamura Ken, Mitchel Olivia, Gilles Casey, Hiesinger William, Fischbein Michael P

Abstract excerpt

BACKGROUND: Smooth muscle cell (SMC) phenotypic reprogramming toward a mixed synthetic-proteolytic state is a central feature of aortic root aneurysm in Marfan syndrome (MFS). Previous work identified Klf4 as a potential mediator of SMC plasticity in MFS. METHODS: MFS (Fbn1C1041G/+) mouse strains with an inducible vascular SMC fluorescent reporter (MFSSMC) with or without SMC-specific deletion of Klf4 exons 2 to...

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Identifiers

PMID: 37128911
DOI: 10.1161/ATVBAHA.122.318509
PMCID: PMC10434826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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