Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

10 Jun 2020

Abstract excerpt

Stress response pathways are critical for cellular homeostasis, promoting survival through adaptive changes in gene expression and metabolism. They play key roles in numerous diseases and are implicated in cancer progression and chemoresistance. However, the underlying mechanisms are only poorly understood. We have employed a multi-omics approach to monitor changes to gene expression after induction of a stress...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32522993
DOI: 10.1038/s41467-020-16747-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolitesPMID 32522993Read ↗

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose DeprivationSemantic proximity Read ↗

Proteomics, Personalized Medicine and CancerSemantic proximity Read ↗

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistanceSemantic proximity Read ↗

Integrated Endoplasmic Reticulum Stress Responses in CancerSemantic proximity Read ↗

Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast CancersSemantic proximity Read ↗

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.Semantic proximity Read ↗

The unfolded protein response and cancer: a brighter future unfolding?Semantic proximity Read ↗

Multi-Omics Analyses Reveal Mitochondrial Dysfunction Contributing to Temozolomide Resistance in Glioblastoma CellsSemantic proximity Read ↗

Multi-Omics Analysis Defines 5-Fluorouracil Drug Resistance in 3D Hela Carcinoma Cell ModelSemantic proximity Read ↗

Activation of the integrated stress response is a vulnerability for multidrug-resistant FBXW7-deficient cells.Semantic proximity Read ↗

Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistanceSemantic proximity Read ↗

Omics Analysis of Chemoresistant Triple Negative Breast Cancer Cells Reveals Novel Metabolic VulnerabilitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.