Article
RANK/RANKL/OPG axis genes relation to cognitive impairment in children with transfusion-dependent thalassemia: a cross-sectional study.
BMC pediatrics - 20 Jul 2022
Mousa Suzan Omar, Abd El-Hafez Asmaa Hosni, Abu El-Ela Mostafa Ahmed, Mourad Mohamed Aboul-Fotouh, Saleh Rasha Nady, Sayed Samira Zain
Abstract excerpt
BACKGROUND: RANK/RANKL/OPG axis was implicated in many pathological conditions. The study aimed to assess the relationship between the studied RANK, RANKL, and OPG polymorphisms and alleles and cognitive impairment in children with transfusion-dependent thalassemia (TDT). METHODS: This study included 60 TDT children. Real-time PCR was done for: rs1805034, rs1245811, and rs75404003 polymorphisms for the RANK gene,...
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